The following drugs haven’t been tested for their effectiveness in treating symptoms of FMS and ME/CFS. But they are known to treat some similar symptoms in the general population. As with any treatment, they may or may not work for you.

This article will look at eight OTC medications and why you should keep them in your medicine cabinet if you have ME/CFS or fibromyalgia.

Overlapping Conditions

Many conditions common to people with FMS and ME/CFS are helped by NSAIDs. These include:

Arthritis Lupus Temporomandibular joint disorder (TMJ)

Improving symptoms of these conditions may help you feel better overall.

Injuries

If you’re injured, the added pain may be enough to trigger a flare. NSAIDs can help manage that pain and therefore might prevent a flare.

For those reasons, it pays to keep a ready supply of OTC NSAIDs such as:

Advil/Motrin (ibuprofen) Aleve (naproxen)

TylenolGeneric non-aspirin pain relieversDozens of combination cold-and-flu products

Unlike NSAIDs, which work by relieving inflammation, it’s believed to help by altering pain signals.

Again, this drug probably won’t do a lot for FMS or ME/CFS pain. But like NSAIDs, it can help with pain from related conditions and day-to-day injuries that, if left uncontrolled, could trigger a flare.

Motion sickness drugs can help control dizzy spells. They include:

Bonine (meclizine)Dramamine (dimenhydrinate)

Check with your healthcare provider or pharmacist before combining them with allergy drugs.

Dry or irritated skin can obviously cause it. But if you have ME/CFS or FMS, you’ll likely feel a stronger itch than someone else would. (That’s thanks to hyperalgesia, which is amplified pain signals.)

It’s also possible that your skin might itch for no obvious reason at all.

Itching is not only annoying, but it can be an added sleep disruption. In addition, vigorous scratching can trigger a pain response in people with FMS.

Anti-itch creams or sprays that contain diphenhydramine can stop itches caused by bug bites, allergies, or other skin irritants. OTC hydrocortisone 1% cream is another option you can try.

Any anti-itch cream should only be used for short periods of time. If problems persist, speak to your healthcare provider.

Regularly moisturizing your skin and using fragrance-free personal care products and detergents can help prevent itchiness. Applying cold compresses or gently rubbing the skin may offer some relief when you do get itchy.

Anti-diarrhea drugs like Imodium (loperamide) can help control this symptom. Diarrhea can dehydrate you—which can, among other things, increase fatigue—so get plenty of fluids.

If you still have diarrhea after taking Imodium, or you need Imodium regularly, talk to your healthcare provider. You might need to look into dietary and lifestyle changes that help manage IBS symptoms.

Fiber supplements are also important for keeping bowel movements regular.

Long-term use of laxatives can make constipation worse. If you need them often, tell your healthcare provider. You may benefit from prescription medications and/or dietary changes.

Some healthcare providers believe these conditions make you more prone to allergies that change over time. That means you may sometimes be surprised by an allergic reaction to something you used to tolerate.

An oral form of Benadryl (diphenhydramine) is good to have on hand in case of a serious allergic reaction. Diphenhydramine is the active ingredient in some OTC sleep aids, so it may help with insomnia, too.

If you’re already on a daily allergy medication, be sure to ask your healthcare provider or pharmacist about what’s safe for you to take if you have a severe reaction.

Sinus headaches Facial pain Problems sleeping

All of that can exacerbate your symptoms.

Regular use of a saline nasal spray or a neti pot can help keep sinuses clear. If saline isn’t enough, ask your healthcare provider about prescription nasal sprays such as Nasacort (triamcinolone) or Flonase (fluticasone).

These include motion-sickness drugs to help with dizziness, anti-itch creams to soothe itchy skin, anti-diarrheal and constipation drugs for related IBS, pain relievers to ease discomfort, and others.

Always check with your healthcare provider before taking medication, even OTC drugs. It’s also a good idea to run them by your pharmacist. They can help prevent negative interactions and ensure your safety.