Dentists recommend a few options when it comes to medicine for pain in your teeth. These options include:
Ibuprofen Naproxen Aspirin Acetaminophen
But not all of these drugs are right for everyone. This article reviews OTC painkiller options, side effects and drug interactions to consider, and other ways you may be able to manage your toothache.
What to Consider
To find the right pain reliever to ease your tooth pain, it helps to understand how these medications work to manage pain. But first, you need to know whether they’re safe for you.
Cavities A cracked or broken tooth An abscessed tooth Gum infections Advanced gum disease Wisdom teeth coming in
While you may be able to manage dental pain at home, you should always call your dentist as soon as possible to be treated and prevent potential complications.
Here are some things to consider when choosing an OTC pain reliever:
Health Conditions
Some medical conditions (e.g., digestive problems, kidney or liver disease) make certain pain medications unsafe. The same goes for pregnancy. Ask your healthcare provider what’s safe for you.
Side Effects
The fact that these drugs are widely used and easily accessible doesn’t mean using them is risk-free.
Some potential side effects of short-term use are outlined for each of the OTC drug options covered here. Think twice about those drugs that pose concerns that may be especially problematic for you.
Drug Interactions
Some pain relievers may not be safe to take with other medications you may be on.
Drugs that may be unsafe to mix with OTC pain relievers include:
Blood pressure drugs: Vasotec (enalapril), Zestoretic (lisinopril), Tenormin (atenolol), Lopressor (metoprolol) Blood thinners: Coumadin (warfarin), Eliquis (apixaban), Xarelto (rivaroxaban) Some antidepressants: Prozac (fluoxetine), Zoloft (sertraline), Cymbalta (duloxetine), Effexor (venlafaxine)
These are just a few of the many possible drugs that may be dangerous to combine with pain relievers. Ask your dentist, healthcare provider, or pharmacist what OTC products are safe for you.
Potential for Overdose
If you take a pain reliever with an active ingredient that is also in another medication you are taking (like a multi-symptom cold medicine), you run the risk of overdosing, which can have harmful side effects.
Ibuprofen
Ibuprofen is one of the most-used OTC painkillers for tooth pain. It’s sold under the popular brand names:
AdvilMotrinNuprin
These medicines are available in tablets, liquid gel capsules, and oral suspensions.
Ibuprofen is classified as a non-steroidal anti-inflammatory drug (NSAID). It works well for dental pain because it relieves pain and lowers inflammation—a cause of many mouth-related aches and pains.
Side Effects
Common side effects of ibuprofen include:
Constipation or diarrheaGas or bloatingDizzinessNervousness
Call your healthcare provider immediately if you experience serious side effects such as:
Difficulty breathing or shortness of breathSwelling in the abdomen, lower legs, ankles, or feetFeverBlisters, hives, or a rashItchingSwelling of the face, eyes, throat, arms, or handsDifficulty swallowing
Naproxen
Naproxen is another NSAID frequently used for tooth pain. It comes in tablets, caplets, gelcaps, and liquid gels.
Brand names include:
AleveAnaproxNaprosyn
To give a sense of how effective the drug can be, research suggests naproxen may be as effective for post-surgical dental pain as the narcotic pain reliever Vicodin (hydrocodone/acetaminophen).
While naproxen and ibuprofen are in the same drug class, one may work better for you than the other.
Side Effects
Common side effects of naproxen may be:
Upset stomach and nauseaHeartburnConstipation or diarrheaGas, bloatingHeadacheDizziness or lightheadednessDrowsiness
Call your healthcare provider right away if you experience:
Changes in visionNumbness or tingling in the hands, feet, or lipsDifficulty or painful swallowingChanges in mental health or moodDifficulty breathing or shortness of breathSwelling in the abdomen, legs, ankles, or feetSigns of infection (fever, chills, sore throat)Blisters, hives, rash, or red skinSwelling of the eyes, face, lips, tongue, throat, arms, or handsExcessive fatigueSevere nausea or vomiting
Dosage instructions on naproxen are different from most OTC pain medications. That’s because it continues working for longer.
Aspirin
An older pain reliever, aspirin (acetylsalicylic acid) is also in the NSAID class. Studies suggest it’s effective for pain from dental problems.
Aspirin comes in many forms, such as chewable tablets, delayed-release and extended-release tablets, and suppositories.
This medication is sold under dozens of brand names. Common ones include:
AnacinBayerBufferinEmpirinExcedrin
Side Effects
Aspirin can cause digestive side effects in some people. Watch for:
NauseaVomitingStomach painHeartburn
Contact your healthcare provider immediately if you develop:
Hives or rashSwelling of the face, eyes, lips, tongue or throatWheezing, labored, or rapid breathingHoarsenessRapid heartbeatCold, clammy skinTinnitus (ringing in the ears) or loss of hearingVomit that’s bloody or looks like coffee groundsBright red blood in stools or black, tarry stools
Acetaminophen
Acetaminophen is a popular way to manage dental pain. However, it doesn’t reduce inflammation like NSAIDs, so it may not be as effective for tooth pain.
Acetaminophen is available under the brand names:
TylenolActaminFeverall
Acetaminophen is especially useful if you can’t take NSAIDs. It is available in several forms that may work for toothache medicine, including:
TabletsLiquid gel capsulesOral suspension
Side Effects
Acetaminophen can cause side effects. Common ones include:
NauseaVomitingHeadacheInsomniaConstipationBlood pressure changesDiarrheaAgitation
If any of these serious side effects occur, call your healthcare provider right away:
Red, blistering, or peeling skinRash or hivesItchingSwelling of the face, eyes, lips, tongue, throat, hands, lower legs, ankles, or feetHoarsenessDifficulty breathing or swallowing
Use As Directed
Any OTC pain medication you take for a toothache is meant for short-term relief until you can get your dental issue fixed. These drugs aren’t meant to help you manage pain long-term so you can avoid going to the dentist.
While your pain may be severe, using more of these drugs than directed can be dangerous. For example, taking too much acetaminophen over a short period can lead to liver failure, which can be fatal.
And excessive or long-term use of NSAIDs can increase your risk of heart attack or stroke. It can also irritate or damage your stomach, intestine, kidneys, or liver.
Always follow the dosage instructions on the packing or given to you by a healthcare provider.
Other Pain Relief Options
You have other options for relieving tooth pain until you can see your dentist. You can use these along with or instead of OTC pain relievers.
Avoid very cold or hot foods and drinks, as well as those that have a lot of sugar or acid (such as orange juice). Floss around the affected teeth to remove any food particles that may be irritating them. Elevate your head while you sleep. This can relieve some pressure that may add to your pain. Rinse your mouth with warm saltwater. For some types of toothaches, you may get relief from applying clove oil.
Summary
Ibuprofen, naproxen, and aspirin are NSAID pain relievers. Because they help reduce inflammation, they’re common choices for dental pain. Acetaminophen may also help with your toothache, but it doesn’t lower inflammation.
Watch for side effects with OTC pain relievers, some of which can serious—especially if you take more than the recommended dose. Make sure you’re not taking drugs that could badly interact with each other.
Your dentist, healthcare provider, or pharmacist can help you choose the best one for you.
A Word From Verywell
Dental pain can be intense and doesn’t always come on during your dentist’s regular hours. If that happens, give your dentist’s office a call. They may have an on-call or emergency number on their voicemail recording.
